HDL Particle Number

The number of HDL particles, measured by NMR spectroscopy.

Ranges vary by laboratory, method, age and sex: always use the range printed on your own report. Why labs differ.

What it measures

HDL-P counts high-density lipoprotein particles rather than the cholesterol they carry. Because HDL particles vary in their cholesterol content, HDL-P can provide a different picture than HDL-C.

Why it matters

Several studies suggest HDL particle number is a more consistent inverse predictor of cardiovascular events than HDL-C, since particle count better reflects capacity for cholesterol efflux. It remains a supplementary marker rather than a treatment target.

What a high result can mean

Higher HDL-P is generally considered favorable. It tends to increase with exercise, weight loss and lower triglycerides.

What a low result can mean

Low HDL-P is associated with insulin resistance, high triglycerides, smoking, inactivity and higher cardiovascular risk.

What affects the result

Measured as part of NMR lipid panels; units are micromoles per liter. It shifts with the same factors as HDL-C. Some labs report large and small HDL-P subclasses as well.

Unit

Usually reported in umol/L.

Also called on lab reports

HDL-P, HDL-P (Total), HDL Particles, HDL P, HDL Particle Count

Related tests: Lipids & Cardiovascular Risk

• Total Cholesterol
• LDL Cholesterol
• HDL Cholesterol
• Triglycerides
• Non-HDL Cholesterol
• VLDL Cholesterol
• Cholesterol/HDL Ratio
• LDL Particle Number
• Small LDL Particles
• LDL Particle Size
• Apolipoprotein B
• Apolipoprotein A1

This page is educational and does not replace advice from a healthcare professional.