Ceruloplasmin
The main copper-carrying protein in the blood.
| Typical reference range | 18–36 mg/dL |
Ranges vary by laboratory, method, age and sex: always use the range printed on your own report. Why labs differ.
What it measures
Ceruloplasmin is made by the liver and carries most circulating copper. It also helps oxidize iron so it can bind transferrin, linking copper and iron metabolism.
Why it matters
Low ceruloplasmin is a key screening marker for Wilson's disease, a genetic disorder of copper accumulation. It also helps evaluate copper deficiency.
What a high result can mean
High levels occur with inflammation and infection (acute-phase protein), pregnancy, estrogen or oral contraceptive use, and some cancers.
What a low result can mean
Low levels occur with Wilson's disease, copper deficiency, Menkes disease, severe liver disease, malnutrition and protein-losing conditions.
What affects the result
Estrogen and inflammation raise it and can mask low values. Interpret with serum copper; Wilson's disease evaluation also uses 24-hour urine copper.
Units and conversion
Usually reported in mg/dL.
- From g/L: multiply by 100 to get mg/dL
- From mg/L: multiply by 0.1 to get mg/dL
Also called on lab reports
Ceruloplasmin, Serum
Related tests: Vitamins & Nutrients
This page is educational and does not replace advice from a healthcare professional.